Tadalafil bindet stark und spezifisch an PDE5 und verhindert so den Abbau von cGMP in den Schwellkörpern. Dies resultiert in einer stabilen Relaxation der glatten Muskulatur und erhöhter Blutzufuhr. Die maximale Plasmakonzentration ist in ein bis zwei Stunden erreicht. Der Metabolismus läuft über CYP3A4, während die Ausscheidung hauptsächlich über den Stuhl erfolgt. Das Sicherheitsprofil ist mit Kopfschmerzen und vasodilatatorischen Symptomen beschrieben. Innerhalb pharmakologischer Profile wird cialis bestellen durch seine Langzeitwirkung differenziert.
Prestigio.com.hr Review:
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